The cees dekker Diaries
The cees dekker Diaries
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‘Yes, that is definitely about right. I seek out a Actual physical knowledge of Organic units inside a base-up way. I do think you might distinguish a few lines of analysis in my team in the mean time. The 1st concerns chromosome construction: How will you get a metre-lengthy DNA polymer folded and organised in this type of microscopic mobile? Now we have developed visualisation strategies that make it possible for us to check how, for instance, SMC proteins loop DNA (movie on Youtube) so that you can build up chromosomes.
You frequently get entangled in discussions about science and religion. You may have also composed many guides on the topic. Don’t you believe that eventually we will know almost everything Which God’s job might be about?
Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
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Our investigate ranges from the biophysics of DNA to artificial cells and further than. Be sure to take a look underneath for the spectrum of our latest initiatives.
‘At the beginning we looked at biological devices having a Bodily watch and acted on the basis in the instruments we realized. It took a few years ahead of we begun Operating far more on the massive biological concerns. I then started to simply call it nanobiology, a time period that did not exist at the time.
Dynamic ParB–DNA interactions initiate and maintain a partition condensate for bacterial chromosome segregation
Knowledge basic procedures regulating the spatial and dynamic organisation in the DNA in Dwell cells.
Dekker began his research on solitary carbon nanotubes in 1993 when he create a new line of investigate to review electrical transport by single natural and organic molecules amongst nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was obtained within a collaboration Using the team of Nobel laureate Richard Smalley. STM and nanolithography strategies were being accustomed to demonstrate that these nanotubes are quantum wires at The only-molecule level, with fantastic physical properties.
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with investigate from scientific tests of DNA loop extrusion and supercoiling to DNA translocation by means of nanopores. More not long ago his analysis has centered on learning chromatin composition and cell division with microbes on chip, although he is also aiming to ultimately Make synthetic cells from the bottom up.
Cees Dekker is Distinguished College Professor at TU Delft. Properly trained to be a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes in the nineteen nineties. Since 2000, he moved to one-molecule biophysics and nanobiology. His present-day investigate concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, specifically SMC motor protein; and (iii) creating a living synthetic cell from lifeless molecules. Dekker is definitely an elected member from the KNAW and fellow towards the APS and the IOP.
2008, 1st observation of protein-coated DNA translocation by nanopores; solved the origin on the ceesdekker electrophoretic power on DNA in nanopores; identified a major velocity boost of microtubules in electric fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim with the pore is highlighted in crimson, and a 3D rendering on the movement on the DNA rod is exhibited.